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Some of the antigens, T5-15 (KIAA1735), T5-13 (Sos1), T11-5 (hypothetical protein MGC4170) were found to be downregulated in many tumors.
Ras effector RASSF5 (NORE1) is found to be downregulated in many tumors, but little is known about the molecular mechanism of its function during cell proliferation.
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It must be noted however, that expression of many of the chemokines were most often found to be downregulated in the NSCLC tumours as follows CXCL1 (64.9%, p<0.01), CXCL2 (81.1%, p<0.01), CXCL3 (59.5%) (Figure 1B).
Among them, ADAMTS1 was previously found to be downregulated in corneas of keratoconus patients compared to control subjects67.
One of these is CEACAM1, which has been found to be downregulated in several carcinomas, including prostate cancer.
The levels of interleukin-10 increased while TNF-α was found to be downregulated in the r-αCS induced splenocytes.
LDHB was found to be downregulated in both the 'R' and the 'D' group compared to controls.
Both Beclin 1 and FYVE-CENT were found to be downregulated in advanced breast cancers.
In contrast to usually reported upregulation, HSP70 was found to be downregulated in Crassostrea hongkongensis [ 129].
In our study, SYT6 was found to be downregulated in the left STG of schizophrenia patients.
The miRNAs found to be downregulated in GBM have been colored in green.
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