Most interestingly, among the 628 genes downregulated in light in all mutant strains, again rgs1 was found to be downregulated.
PD-L1 is an immune checkpoint protein, recently found to be downregulated following MYC inactivation.
HEXIM1 protein level has been found to be downregulated by estrogens.
Among them, ADAMTS1 was previously found to be downregulated in corneas of keratoconus patients compared to control subjects67.
One of these is CEACAM1, which has been found to be downregulated in several carcinomas, including prostate cancer.
The levels of interleukin-10 increased while TNF-α was found to be downregulated in the r-αCS induced splenocytes.
Interestingly, GR activity was found to be downregulated by 40% in the parasite compartment.
In agreement with the array results, GIMAP5 was also found to be downregulated by RT-PCR.
Twelve miRNAs were highly expressed, whereas nine were found to be downregulated.
Both Beclin 1 and FYVE-CENT were found to be downregulated in advanced breast cancers.
Cx43 was found to be downregulated even in adult mice with HGF expression suppressed the day following birth.
