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There have been other approaches based on whole genome comparisons, where highly conserved non-coding regions were found to be associated with developmental genes [ 34, 46, 47].
During subsequent studies over the last decades, a variety of similar cellular extensions were found to be associated with developmental processes.
Interestingly, we identified eight markers that were found to be associated with developmental stage at all three time points, whereas the other markers were only detected at one or two of the time points.
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Some of them were found to be associated with leaf developmental stages.
As in migraine, male gender was found to be associated with remission and early developmental disorders to be associated with persistence.
Notably, a large number of conserved noncoding elements (CNEs) identified in these genome-wide comparisons were found to be associated with TF-encoding and developmental genes.
Using a range of bioinformatic analyses, distinct modules of co-expressed genes were found to be associated with specific flag leaf developmental stages.
However, the majority of mice lacking both proteins showed developmental defects, which was found to be associated with ectopic hypermethylation [ 51].
The antenatal factors we found to be associated with disruption of both GI and CSA, birth weight and birth OFC, have previously been related to developmental outcomes in preterm infants.
Some of the best documented examples are found in grasses, where developmental genes encoding mainly transcription factors such as TB1 and TGA1 [5], [5], were found to be associated with domestication (see [6] for exhaustive review).
Living near a major highway may be associated with developmental delays in children.
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