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The high shear mixer is found to be an efficient mixer for dry blending prior to the wet massing of a low dose drug formulation when impeller speed and chopper speed were carefully selected.
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Mixing time has been found to be a function of vessel diameter, with the smaller vessels shown to be more efficient mixers.
Generally, the rotary processor was found to be a suitable alternative to melt pelletization in a high shear mixer.
Since material points stayed on their streamlines near to rotor wall in the cam and banbury mixer, roller mixer was found to be generally more effective and efficient, although there were still areas of poor mixing found in all.
The power curves of the mixer were obtained, and the mixer efficiency in terms of power consumption was found to be similar to other impellers used to mix highly viscous non-Newtonian fluids.
Moreover, the power consumption of the static mixer was evaluated and found to be almost negligible.
The mixer constant A′ was found to be 0.008 ± 0.0018 m3/radetermineded using Newtonian fluids and Eq. (14).
However, TPR factor was found to be independent of process design, such as the filling level of the mixer.
Inclusion of laminating mixer units inside the mixing cell was found to facilitate the mixing of the incoming streams.
The addition of a mixer is effectively found to contribute to cement reduction.
The power consumption and the mixing time data revealed that the Scaba-anchor coaxial mixer in the co-rotating mode was the most efficient mixer among the coaxial mixers explored in this study.
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