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Intriguingly, Notch2 was shown to be highly expressed in GBM, and the Notch2 gene was found to be amplified in many primary GBM cell lines.
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The minimal region of 1q21 was found to be amplified in more than 50% of HCC patients.
MYC was found to be amplified in ESCC cell lines and in primary tumors [ 14].
MYCN oncogene content was assayed in 47/51 tumours and found to be amplified in 17 (37%).
Apart from MYCN, no other genes were found to be amplified in all cases with amplification.
AIB1 has been found to be amplified in about 10% of breast cancers [ 25].
BTBD7, KHDRBS1, PARP1 and RAB1A were all found to be amplified in progressive leukoplakia lesions and OSSCs and not amplified in non-progressive leukoplakia.
In addition to its key role in development, TBX3 expression has also been found to be amplified or over-expressed in many different cancer types including breast, cervix, ovary, pancreas, liver cancers and melanomas [ 9- 14].
Clone g10d12 was also found to be amplified and overexpressed in cell line SJNB-6.
PIK3CA was specifically found to be amplified and overexpressed in ovarian and cervical cancer [ 6- 9].
The PI3KCA gene has been found to be amplified and overexpressed in several types of cancers.
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