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The exon 1 of Htt has been used extensively in vitro and in vivo to study Htt aggregation and toxicity because N-terminal cleavage fragments of the full-length protein likely play an important role in pathogenesis in neurons; Htt exon 1 causes disease progression in transgenic mice, and N-terminal Htt fragments have been found to be a large component of neuronal inclusion bodies.
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Since AGO1 is found to be a piNG-body component, the functions of the large granules in the microRNA-mediated mRNA silencing can also be expected.
Medications are frequently found to be the largest component of expenditure on diabetes [ 47].
Similarly, in another study conducted in Canada, illness-related disability was found to be the largest component of indirect costs ($76 million) [ 29].
However, medication costs were found to be the largest single component of direct costs from the patient's perspective, in both studies [ 15, 42].
Large polycyclic aromatic hydrocarbons (LPAHs) were found to be the major components in the complex mixtures.
One of the components of P-body complexes is a protein called Mov10, which was found to be associated with APOBEC3G in large complexes [6], [9].
Large weight gain predicted all components except low HDL-C, on the other hand weight loss found to be protective only against high WC component.
A suprisingly large part of the skin components found to be differentially expressed are located in the cornified envelope.
Three components were found to be the best solution, although interpretation and the labeling of the components might change in a larger study.
Extraction of lobster components using microwave, ultrasonic, and supercritical fluid extraction were found to be promising techniques that could be used for large-scale production.
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