While the associations we found in this hypothesis-generating study were modest and need to be confirmed by follow-up in larger studies, we suggest that this approach may prove useful for identifying functional SNPs that contributing to a phenotype via an impact on gene expression.
An explanation for this might be found in the hypothesis that when investigating the relationship between lung function and pain, confounding and selection bias are very likely to occur.
After the combined analysis, 167 SNP sites were obtained as risk loci in EAGLE (Table S2) and good association consistency between EAGLE and PLCO datasets was found in the hypothesis regarding amplification and 1(b)).
Although these results can not be extrapolated to CAM users in general, the patterns found in this study generate hypotheses worthy of further exploration.
Inversely, a positive correlation between metabolism and whole-brain connectivity was found in this region, supporting the hypothesis of early amyloid-related dysfunction in this key hub region.
The interlinkage of redundant sub-networks found in this system supports the hypothesis that interconnection among feed-back loops or small nonlinear systems confers robustness to biological networks and may constitute an important trait in network evolution [ 49].
The inverse association of TXNRD1 and TXNIP with MFI found in this study supports the hypothesis that the maintenance of an active thioredoxin system is advantageous to the tumor cells because it limits oxidative damage and enables them to survive.
The very low cs-HRs with increasing volume for early technique failure found in this study are consistent with this hypothesis (see supplementary material); however, the sensitivity analysis showed that the association persisted even under a scenario of strong residual confounding, suggesting that there is a true, protective effect.
Nine of the twelve MmpLs, large membrane-spanning proteins involved in the translocation of lipids, were found in this analysis, consistent with others' hypotheses of their role during infection and their active involvement in virulence [28], [29].
In general, the pattern found in this table appears to fit the hypothesis that persons less healthy at baseline were less likely to become long-term participants [ 42].
To some extent, the lack of strong responses found in this study lends support to the hypothesis that it is the indirect effects of cold temperatures that limit plant production through low nutrient availability, rather than low temperatures per se [ 37].
