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It forms asymmetric antiparallel homodimers that were found functional in isotropic bicelles; global conformational exchange between identical inward- and outward-facing states was found and exchange rates were measured quantitatively.
Unexpectedly, the second PP1 binding peptide containing the HYNE motif, although it was found functional in oocyte model, was not active as an antiplasmodial suggesting that native PfI2 expressed by P. falciparum could displace the HYNE peptide.
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In our previous studies, we found functional genes in G. uralensis such as those of HMGR and SQS were subject to CNV 23 25.
Adamcsek et al. developed the CFinder tool [ 6] that found functional modules in PPI networks using the clique percolation method [ 7] to detect k-clique percolation clusters.
Similarly, Guo et al. [28] found functional markers segregating in at least five families and explaining >5% of the phenotypic variance can be detected with adequate power.
We found functional iNKT cell defects in the prostate cancer model TRAMP (transgenic adenomacarcinoma of the mouse prostate) resembling those functional iNKT cell defects seen in human malignancies.
We also found functional active NPY receptors in the inner retina using [S]GTPγS-binding assay.
This differential expression signature finds functional validation in our in vitro studies, which revealed that IFNγ inhibits definitive, but not primitive, erythroblast maturation.
More generally, a likelihood score for the density of a subgraph can be used in (greedy) optimization algorithms to mine dense subgraphs, such as in CEZANNE, which finds functional modules in gene co-expression networks [ 101].
Both of these issues could have led to a loss in the necessary statistical power to find functional enrichment in the CHI gene clusters.
Their unique morphologies and super physical properties can also find functional applications in catalysis, batteries, fuel cells, environmental adsorption and electrochemical sensing.
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