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We found fever duration over 7 days was associated with a bad outcome.
The physical examination found fever, conjunctivitis and painful erythematous edematous papules, with occasional pustules, involving the neck, upper back and extremities.
A 2011 systematic review covering a similar time frame identified 12 studies meeting similar criteria; authors found fever plus cough and fever/cough/acute onset heuristics to have areas under the receiver operating characteristic curves of 0.70 and 0.79, respectively.
Ceroni et al. observed that fewer than 15%% of their children were febrile, 39%% had normal C-reactive protein (CRP) levels, and only 9 % had high WBC counts [ 29]; Dubnoz-Raz et al. found fever in 25%% of their patients, a WBC count of >15,000/mm in only about 50%%, and CRP levels within the normal range in 22 % [ 2].
Passive surveillance in Niger found fever, gastrointestinal disorders, convulsions, headache, and urticaria to be reported most frequently, although the authors note the likelihood that many reported events (particularly of fever and convulsions) were coincidental infectious diseases and likely caused by malaria, given that the campaign occurred in September, during the malaria season [ 22].
A Finnish group who used a matched case-control study in children aged ≤13 years to compare confirmed influenza patients with those who had respiratory symptoms but were influenza-negative found fever to be the only reliable predictor of influenza [ 54].
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In a previous study [ 17], no direct relation was found between fever relapses and recurrence of rickettsemia, since fever was recorded in only 21% of the times where infected neutrophils was detected in the blood of E. phagocytophila infected lambs.
This finding is similar to a previous study that found a fever duration of <4 days for patients with influenza [ 25], while the average length of fever in dengue patients was approximately 5 days [ 39], coinciding with the disappearance of viremia.
Spanish missionaries found that fever was treated by Amerindians near Loxa Peruu) with powder from Peruvian bark (later established to be from any of several trees of genus Cinchona).
We found typhoid fever concentrated in three regions of the country, each with differing temporal patterns.
No association was found with fever, vomiting, or blood in stool with genes (data not shown).
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