A small open-label study [109], comparing the effect of yet another COX 2 inhibitor, celecoxib 400 mg, with that of a classic NSAID (Naproxen 550 mg) for a single migraine attack, found similar efficacy for the two drugs, but significantly fewer in the celecoxib group reported epigastric pain.
There is some evidence that 177Lu-DOTATATE may be even more effective than 90Y-DOTATOC although the only comparison of these two agents in the same study is from a recent retrospective report which found similar efficacy for the two radioactive drugs [38].
Two of the male circumcision trials found no efficacy for male circumcision in reducing HSV-2 seroincidence [102], [103], [106], Bertran Auvert, private communication.
In one randomized controlled study of extended-release tolterodine 4 mg/day in patients with urge incontinence and urinary frequency, no differences were found for efficacy, tolerability, or safety between older and younger patients (Wefer et al 2001).
Indeed, looking at available clinical data, a randomised controlled trial with a non-inferiority design comparing the loose and fixed-dose combinations has found similar efficacy rates for both combinations in paediatric falciparum malaria in Burkina-Faso [ 20].
They also found "evidence of efficacy" for postoperative dental pain, and "reasonable studies" showing pain relief for other conditions.
The meta-analyses of urogenital treatment efficacy found that the efficacy for azithromycin was lower for those with symptomatic infection compared with doxycycline [ 18].
A meta-analysis of 150 randomized double-blind controlled trials comparing the efficacy of typical and atypical antipsychotics found better overall efficacy for the atypical antipsychotics on positive and negative symptoms compared with the typical antipsychotics.
For example, in the present analysis, we found slightly lower efficacy for plant sterols than for plant stanols in the dose category ≥ 2·0 dose < 2·5 g/d; this was probably due to a larger number of liquid food formats among the plant sterol studies than among the plant stanol studies.
No study was found on efficacy of CS for glove disinfection.
