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Similar to aged lens tissue, we also found accumulation of Ub-containing moieties, particularly in insoluble fractions, in lenses in which K6W-Ub was expressed at higher levels [8].
At early stages of S phase, we found accumulation of Y-structures and the formation of a pronounced fork pausing site (Fig. 5C, red arrows, fractions 18, 22, 25).
When we sequentially recovered the cells and stained for actin fibers, we found accumulation of radial actin bundles in cofilin-1 silenced cells eight hours after treatment with cytochalasin D. These results suggested the presence of cofilin-1 enhanced actin depolymerization and led to decreased formation of actin stress fibers as a prerequisite for recovery and cellular spreading in culture.
Third, we have found accumulation of PAT around the arterioles that regulate muscle perfusion.
The authors found accumulation of HTLV-I-infected T cells expressing TCR with a conserved motif in both HTLV-I-associated and idiopathic SS [ 18].
In our study, we found accumulation of p53 in the cytoplasm of only those cells taken from infected mice after day 25 post-infection.
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We searched the savannah extensively and found a number of sites where trees had similar markings, and in many places we found accumulations of stones inside hollow tree trunks.
However, we did not find accumulation of tRNA fragments as described in roots of phosphate-starved plants [ 38] or nitrate-starved seedlings [ 33].
Since all ISCC cases are HPV-16 or 18 positive, it is not expected to find accumulation of the p53 nor the p53-induced proteins in these cases.
For example, using a proteomic approach, Parker et al. [ 73] did not find accumulation of such proteins in sIBM nor did they detect even one peptide from β-amyloid.
DOI: http://dx.doi.org/10.7554/eLife.06763.028 Extending these studies, we find accumulation of multiple SUMO conjugates (in addition to Top1cc [ Stingele et al., 2014]) that correlates with synthetic sickness in wss1Δ tdp1Δ cells.
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