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Under phototrophic conditions we found a repression of 4 Htr encoding genes, i.e. htrI, htrVIII, basT, and htr18.
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Consistent with these results, we also found a dramatic repression of several elongase genes.
Previous work had found a global translational repression during mitosis (Fan and Penman, 1970).
We also found a strong translational repression of two key regulators of centriole duplication, Plk4 and CP110 (Chen et al., 2002; Habedanck et al., 2005).
We therefore validated the effect of d.n.FoxO on the C26-induced increase in atrogin-1 and MuRF1 in TA muscles via qRT-PCR, and found a greater magnitude of repression than indicated on the microarray (~40% repression of atrogin-1, ~60% repression of MuRF1), both of which reached statistical significance (p < 0.05, data not shown).
Both argue that the youths are indeed rebels, who feel they have found a new force of repression as depraved as the Ancien Régime: l'anglo-saxonisme.
In line with the PAI-1 activation observed in superficial tumours, we also found an early stage repression of the miR-143/-145 cluster without a significant difference between invasive and superficial tumours.
We found a general trend towards gene repression after a period of 24 h at low temperature (Fig. 7).
We further found a similar trend of CCA1 repression and TOC1 upregulation in the triploid and tetraploid hybrids.
Stratified luminal epithelium is observed in the uterus of Wnt7a-null mice (Miller and Sassoon 1998), and in the present neonatal Gen model we found Wnt7a repression and a marked up-regulation in the oviduct of genes that are normally observed in stratified cervical/vaginal squamous epithelium.
Although the overall percentage of down-regulated genes at the larval stage in the differential expression datasets is 65%, we find a significantly stronger bias towards repression in the Ubx-bound genes (76%, p = 0.0004; Figure 2).
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