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Exact(26)
In our study, we found a mortality rate of 11%, which is higher than several previous studies reported [3, 5].
Several small retrospective studies have found a mortality rate ranging from 75%to100%0% in this population receiving RRT [19, 23, 25].
When we compared the upper 20% MPO levels with the lower 80% MPO levels, we found a mortality hazard ratio of 1.8 [CI 1.07 2.88, P = 0.02].
Another study, from Malawi, found a mortality of 47% among patients followed-up for 32 months [146].
The AMPATH programme was also included in our analysis: we found a mortality estimate at one year of 10.2%, similar to the double-sampling study [21], when we used the estimate for excess mortality in patients lost to follow-up from the meta-regression model [5].
A recent RCT of transfer to an ECMO centre found a mortality benefit when compared with conventional therapy [ 90].
Similar(34)
Some authors found increased mortality for patients admitted during off-hours [ 2- 5], while others did not find a mortality difference [ 6- 10].
We found a similar mortality of 11.6%, suggesting that overall mortality of PCP has not changed a great deal.
Nevertheless, the Colombia group found a lower mortality rate [ 35] and another study found no mortality at all [ 36].
In high-frequency ICUs, we found a similar mortality, although patients in these ICUs had significantly higher predicted mortality.
After stratifying studies into tertiles of quality, we found a lower mortality rate in high-quality studies and a progressive increase in mortality for intermediary and lower tertiles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com