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In a further 15 patients (20%), we found a discordance between clinically assigned risk and MP results.
In 12 cases (12.8%; 95% CI 1.8 6.4%), of which six involved synchronous metastases at diagnosis and six showed metachronous metastases development, we found a discordance in KRAS mutation status between primary tumors and metastases.
In this study that evaluated a large number of samples, we found a discordance rate of 4.0%; 22 of 552 unique tumor samples initially found to be HER2-negative by local testing were determined to be HER2-positive upon central retesting.
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What's more, Dr. Osborne compared the outcomes of two ranking programs — one by U.S. News and World Report and the other by Healthgrades — and found a "large discordance" in their results.
Overall we found a 10% discordance rate (17 out of 168) between original and confirmation assessment of HER-2 status.
After central testing became mandatory in the NCCTG N9831 trial, an expanded analysis (N = 2535) found a lower discordance rate of 12%.
These authors found a strong discordance between a phylogeny based on concatenated conserved amino acid sequences and reconstructions based on gene order.
Schwartz et al. [ 18] also found a greater discordance between uni- and bidimensional measurements in more ellipsoid lesions compared with spherical lesions.
Furthermore, we found a lower discordance rate among patients who did not receive prior anti-cancer therapy versus patients who were previously treated.
We found an appreciable discordance between final clinical and final pathologic response in our patient group, with almost a half of clinical responders (13 of 24) failing to obtain a pathologic response.
Comparison of the genotype predicted and the measured metabolic status (Table 1) found a statistically significant discordance (P<0.0005).
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