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The design of synthetic bone grafts to foster bone formation is a challenge in regenerative medicine.
These data are particularly interesting for small proof-of-concept studies aiming to combine strong anti-inflammatory/anti-erosive drug therapy with interventions that foster bone formation and repair.
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Our study shows that fostering bone formation by Scl-Ab reverses systemic, periarticular and local bone loss in inflammatory arthritis.
5 6 Scl-Ab, but not TNFi, reversed systemic osteopenia in the spine, as well as periarticular osteopenia in the tibia, suggesting that fostering bone formation may be an effective treatment strategy for trabecular bone loss during inflammation.
This field has gained insights into the mechanism of inflammatory bone loss, in particular of how inflammatory cytokines like TNF-alpha, IL1 or IL6 foster bone resorption and inhibit bone formation, resulting in an imbalance of bone homeostasis and thereby precipitating bone loss.
See also bone formation.
FLUORIDE Encourages strong bone formation.
Bone formation proceeds outward from these centres.
The role of bone morphogenetic proteins in endochondral bone formation.
(a) TAK1 signaling pathway regulates bone formation.
In children and teenagers, bone formation exceeds bone breakdown.
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