Exact(25)
Prevention of forward trafficking predictably altered the subcellular distribution of KCNE2 from its prominent peripheral localization towards the intracellular compartments where it acquired considerable overlap with HERG.
Differences in the lipid composition and bilayer thickness of ER, Golgi and plasma membranes underlie the proposed mechanism by which transmembrane segment length determines efficiency of forward trafficking.
Other molecules that may modulate these events include CD2-associated protein (CD2AP) which participates in endocytosis of polycystin-2, while PIGEA-14 is involved in forward trafficking from the ER to the Golgi[51].
Since the lower molecular weight species of HERG has been proposed to represent a fraction that is immature and still being trafficked through the ER/Golgi system [34], its persistence during the pulse-chase may reflect co-assembly and reduced forward trafficking rate conferred onto HERG by KCNE1.
Overall it isn't a very thorough investigation of potential effects on forward trafficking.
Our results demonstrate that PKC activation fosters ADAM10 forward trafficking towards the postsynapse inducing ADAM10 exit from the ER.
Similar(35)
Proxy servers typically take longer to respond to commands because they have to forward traffic elsewhere.
The Nokia operating system IPSO is a secured operating system (OS) optimized to forward traffic.
The difficulty of the problem stems from the fact that node pairs can forward traffic to one another, resulting in cyclical dependencies.
Check Point's SecurePlatform and Nokia's IPSO operating systems are highly secured operating systems (Oss) optimized to forward traffic and for firewall duties.
"The server that was found in Bahrain is very likely a custom-built software that was simply used as a proxy to forward traffic between two or more systems.
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