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The dogs lunged forward; paws ripped into the snow.
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Because i) Forward paw kinematics are normal, which would not be the case if there was a failure in an inverse model.
We expected that a failure of an inverse kinematic model would cause changes in forward paw trajectories, which were surprisingly intact in pcd.
The only panel in Figure 3 where we claim that pcd and controls are the same is the forward paw trajectories shown in Figure 3E.
10.7554/eLife.07892.010 Figure 3. Differences in forward paw trajectories in pcd can be accounted for by walking speed and body size; impairments are restricted to off-axis movement.
In light of these extensive anatomical defects and the existing body of literature on mouse ataxia, the remarkable preservation of forward paw motion in pcd was surprising.
This surprising result reveals that even detailed forward paw trajectories are normal in pcd mice, once changes in walking speed and body size are taken into account.
Surprisingly, we found that the instantaneous forward paw velocity profiles of pcd mice were not distinguishable from those of size-matched controls, across speeds.
The preservation of forward paw kinematics was completely unexpected based on the existing literature and it changes the way we think about ataxia.
The statistical models we developed based on a library of data from wildtype mice accurately predicted the forward paw motion of ataxic pcd mice.
As I understand it, the main consistency is in the x-axis forward paw motion, while there are changes in vertical and mediolateral paw motion and in joint angles.
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