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The TEM images are taken at the same magnification with the scale bar, 10 nm. Figure 3 and Supplementary Movie 6 present the detailed forward and reverse processes of the nanomechanical cleavage of an 11-layer MoS2.
The association rates k1 and k2 and the dissociation rates k − 1 and k − 2 account for the substrate binding and product release forward and reverse processes, respectively.
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We characterized the entire trajectory including both the forward and reverse process in terms of phenotypic reversibility (function or enzymatic activity), genotypic irreversibility (sequence), as well as in terms of the underlying molecular basis (structure and mechanism).
The (i) and (ii) represent, respectively, the forward and reverse tunneling processes of electrons driven by the temperature difference.
Assuming only that the codon bias is time-invariant, the approach-to-equilibrium kinetic formalism captures in a single exponential equation both the forward and reverse rate processes at two fold redundant sites.
The induced electrostatic potential also cause forward and reverse ion exchange processes to proceed at significantly different rates, i.e. these are asymmetric.
The constitutive model was also found to predict the magnitude of the yield shoulder during unloading and reloading, but to underestimate the gradual nature of both the forward and reverse plastic deformation processes as well as the strain recovery at zero load.
Importantly, our finding that both receptors (Ephs) and ligands (ephrins) are present on the maturing oligodendrocytes show that both forward and reverse signaling is possible between oligodendrocyte processes and axons.
Both methylated and unmethylated alleles were identified and fully characterized in a series of 12 PCR products through a bi-directional sequencing process and specific forward and reverse primers that did not contain CpG sites (Additional file 2: Table S2).
It further implies that balancing Eph-ephrin forward and reverse signaling is important in the selection process of axons to be myelinated.
Sequencing was processed always in the forward and reverse directions using software Sequencing Analysis, MatchTools and Navigator (MatchTools Allele Identification package, Applied Biosystems, Foster City, CA, USA).
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