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The selected formulations were further tested for their capabilities to reduce oil water interfacial tensions (IFT) to ultra-low value.
Four optimized formulations were further subjected in this work to lyophilization to promote their long-term physical stability and were fully characterized.
The solid self-microemulsifying spray dried (S-SMSD) and solid self-microemulsifying freeze dried (S-SMFD) formulations were further evaluated with optimized liquid SMEF.
In order to confirm whether the in vitro release data were able to translate into in vivo oral absorption dates, the oral absorption kinetics of C-glucose formulations were further studied in rats.
Hence, the activities of both liposomal formulations were further analysed in terms of DXR sensitivity on each cancer cell tested in vivo; TGI treated with DXR was used as an index for this sensitivity as shown in Figure 6B.
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The cytotoxic potential of individual formulations was further studied by live/dead assay.
Moreover, comparisons between experimental and analytical results obtained by respective analytical formulations are further discussed.
The available formulations are further compared with other thermodynamic approaches of constitutive developing.
The antitumor effect of different formulations was further quantified by IC50 value, which is defined as the amount of drug required to kill 50% of cells in the designated time interval (Fig. 7).
The higher entrapment efficiency observed with the coated formulations was further investigated using optical microscopy (Nikon model TiU coupled with Photometric Coolsnap EZ 20 MHz monochrome camera) to investigate how the beads dried (data not shown).
The use of dynamic dialysis in drug release studies of liposome and other nanoparticle formulations is further discussed and experimental artifacts that can arise without adequate validation are illustrated through simulations.
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