All the formulations were found to be suitable for formulating in terms of physicochemical characteristics and there was no significant interaction noticed between the drug and polymers used.
The formulations were found to be robust to dilution and showed cloud point at 80 85 °C.
The formulations were found to be stable after 3 months of accelerated stability studies.
The maximally tolerated dose of all formulations was found to be 2000 mg/kg.
Pharmacodynamically, no significant differences in SDMT scores between the two formulations were found.
All formulations were found to be non-skin irritating and safe to use.
The formulations were found to mask the unpleasant taste of caffeine citrate significantly.
No observed difference in zeta potential values for both NPs formulations was found.
The DDG, DDG2 and DDG3 formulations were found to be much more accurate than the above three existing flux formulations.
The resulting formulations were found to be very easy to process and they were injection moulded to get flat substrates.
