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The purpose of this study was to apply experimental design methodology (DOE) to the development and optimization of tablet formulations containing high amounts of paracetamol (more than 70%) and manufactured by direct compression.
: Formulations containing high concentrations of aspirin often smell like vinegar because aspirin can decompose through hydrolysis in moist conditions, yielding salicylic and acetic acids.
Genetic selection of Atlantic salmon families better adapted to alternative feed formulations containing high levels of vegetable ingredients has been suggested to ensure sustainable growth of aquaculture.
To improve systemic availability, formulations containing high concentrations of curcuminoids were solubilized in either serum [ 29] or 2-hydroxypropyl-γ-cyclodextrin (HP-γ-CD) and injected into Alzheimer transgenic mice.
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Locust bean gum and κ-carrageenan improved cooking yield and reduced expressible moisture in formulations containing higher proportions of potato starch.
Formulations containing higher percentages of gums and lower water content led to an appropriate behavior for industrial production of these doughs.
Similar experiments with poorly-curing formulations containing higher Na and Si contents show that their unpolymerised components form crystalline nepheline (NaAlSiO4) at 800 °C, prior to melting at about 1100 °C.
Whether formulations containing higher concentrations or different rates of infusion could be responsible for greater renal protection deserves further investigation.
In contrast, the contour plot for the B/Malaysia strain showed that the highest desirability was obtained with formulations containing higher concentrations of AS03 (and3B AS03AS03A) together with MPL.
It can also be noted that regardless of the drying method, the formulations containing carrageenan resulted in larger microparticles, especially the formulations containing higher contents of carrageenan (FD3 and AD3), as compared with the formulations containing alginate only (FD1 and AD1).
Based on the dose-ranging study presented here, the vaccine formulation containing 20 μg of gD-2t antigen was chosen for further development because it elicited humoral and cellular mediated immune responses that were comparable to responses elicited by formulations containing higher doses of antigen (40 or 80 μg of gD-2t antigen).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com