Surfactants, polysaccharides and salts are added to pharmaceutical products to stabilize protein formulations and to avoid denaturalization and aggregation [1, 5, 6].
The microparticles were spherical for the three formulations and essentially free of aggregation.
Formulations reduced aggregation of native Fab and IgG relative to vehicle up to 50% and enhanced transepithelial permeation rate up to 2.8-fold.
A crucial step in the development of therapeutic monoclonal antibodies is the selection of robust pharmaceutical candidates and screening of efficacious protein formulations to increase the resistance toward physicochemical degradation and aggregation during processing and storage.
These results extend the current knowledge on molecular interactions between globular proteins and non-ionic surfactants, and contribute to the fine-tuning design of protein formulations using polysorbates as excipients for minimizing the undesirable effects of protein adsorption and aggregation.
In protein formulation development, shaking stress is often employed to assess the physical stability of antibody formulations against aggregation.
Climate-specific wildlife news and aggregation.
Zoghbi, H.Y. & Orr, H.T. Polyglutamine diseases: protein cleavage and aggregation.
Ruggeri, Z.M. Mechanisms of shear-induced platelet adhesion and aggregation.
Horror specialises in confrontation and aggression; the eerie in intimation and aggregation.
