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In the formulation work, statistical experimental design is commonly used to obtain a product with the required characteristics.
There were several experimental design techniques used for formulation work such as factorial design and mixture design.
For example, a class I drug might need much less formulation work compared to a class II drug where solubility must be improved (Almukainzi et al. 2014).
The approximation effort is replaced by an integral formulation work leading to an algorithm providing the exact yearly-integrated solution, with computation requirements similar to that of a single date simulation.
So far, solid formulation work has been performed with alum adjuvant for epidermal powder immunization (EPI) with hepatitis B [15], [16], [17], and diphtheria and tetanus toxoids [17].
As a result, the start of hexavalent vaccine formulation work by other DCVMs could be delayed by at least three to five years.
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But he cautioned that in-vitro testing does not demonstrate how a final formulation works off the shelf.
The proposed formulation works well for non-matching discretizations on adjacent contact interfaces and handles self-contact naturally.
This formulation works well for the representation of coarse movements, but the motion templates are not connected to specific parts of the DPM model.
Finite volume method (FVM) has its merit in dealing with conservation law problems and its integral formulation works well with relatively low solution regularity.
In its classic formulation, working memory consists of separate storage buffers for verbal and visuospatial content, as well as executive processes that act upon the information in the storage buffers (Baddeley 2000).
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