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A challenging sustained release formulation with high content of a poorly flowing low density drug was selected.
These results suggested that taxifolin nanoparticles might have potential value to become a new oral taxifolin formulation with high bioavailability.
A central composite design was employed to optimize liposomal formulation with high encapsulation efficiency and small particle size.
Understanding the aerosolisation mechanism of carrier-based formulation with high drug loadings is crucial to developing high-dose dry powder inhalers.
A novel dry powder formulation with high percentages of respirable particles coupled with a cost effective inhaler device is an appealing platform for TB drug delivery.
This paper investigated the effect of carrier-drug mass ratio in different conditions based on the combined computational fluid dynamics (CFD) and discrete element method (DEM) approach, aiming to develop better understanding of the aerosolisation mechanism of carrier-based formulation with high drug loadings.
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Although the formulation with higher mass fraction of HFA 134a can generate smaller droplets, it cannot produce steady puffs with relatively low mass flow rate.
Regarding membrane fluidity, two behaviors were distinguished in the bilayer: CLA at both formulations disordered the outer membrane zone increasing its fluidity, but the formulation with higher CLA content caused a decreased fluidity near the center of the membrane.
Recently, a new formulation with higher water solubility (diclophenac DHEP) has demonstrated effect over placebo, and in lower doses than diclophenac potassium [110].
In the present study, we report a new raloxifene formulation with higher cytotoxicity against CRPC cell lines compared to free raloxifene.
It was found that the formulation with low amount of xanthan gum (40% w/w) showed a low release rate compared to formulation with higher concentration (60% w/w).
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CEO of Professional Science Editing for Scientists @ prosciediting.com