The effect of formulation (type of polymer, PZZ concentration, amount of excipients) and process variables (feed rate, spraying distance) on the mechanical and drug release properties of the thin films were studied by Design of Experiments (DoE).
A table listing vaccine formulation, type of adjuvant, animal model, route of immunization and challenge with Y. pestis was provided in our recent review on this subject.
Problem formulation, types of plasticity and fracture models and their parameters are estimated independently in the context of their effect on the accuracy of numerical solution.
Such data, combined with information on the type of formulation, types of excipients, and methods of administration [ 34], will help develop and validate nonproprietary methods to assess behaviors associated with concepts such as "acceptance", "rejection" and "palatability".
Furthermore, the mixed random effects model found no statistically significant difference in Cmax or AUC between the formulation types for any of the three drugs (results not shown).
Indeed, HA preparations may broadly be classified according to their MW and formulation type: solutions of low MW (500 1200 kDa), solutions of high MW (6000 kDa), cross-linked HA and solutions of non-animal stabilized HA (NASHA) [10, 11, 12].
Caking on vibration was dependent on the formulation: type and concentration of surfactant; type of oil.
More importantly, and regardless of the formulation type, clinical trials require pre-clinical assays and models to predict the treatment efficacy.
Formulation parameters (type of biopolymer, type of oil and stabilizer and its concentration, volume fraction and content of internal aqueous phase, time and regime of mixing) were investigated.
Formulation parameters (type of polymer and its concentration, stabiliser concentration and volume of internal aqueous phase) and physicochemical characteristics (size, zeta potential, encapsulation efficiency, in vitro release profiles and in vitro stability) were investigated.
These functional properties are used in many formulation types, like suspensions, various types of emulsions, mixed micelles, solid dispersions, drug phospholipid complexes, etc. 39, 40.
