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Another such standard nanoparticle formulation specific for lung cancer cells, called expansile, was developed by Griset et al. in 2009.
Then, by applying response surface methodology coupled to desirability function, an optimal formulation, specific for the heterotrophic growth of Chlorella sp. that allows maximizing lipid concentration was obtained.
Where appropriate we have highlighted unusual nanoparticle morphologies that are accessible, and formulation specific, as well as interesting properties associated with certain final nano-objects.
Secondary drying is complete when the desired residual water content is achieved for long-term stability (product and formulation specific).
Our data demonstrated that the efficacy of spore killing is formulation specific and cannot be generalized.
The data presented herein suggest that it may be more appropriate to make ABHR application recommendations based on formulation specific efficacy data.
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Moreover, these approaches are based upon drug properties alone and are not appropriate for estimating potential formulation-specific FE on modified or controlled release products.
In contrast, physiologically-based mechanistic models can consider the scope and interplay of a range of physiological changes after food intake and, in combination with appropriate in vitro drug- and formulation-specific data, can make quantitative predictions of formulation-specific FE including the inter-individual variability of such effects.
Preparation of formulation-specific guidance indicating the required tests is under consideration in Japan, as a method to achieve BE between products and their quality in a rational development process.
Herein the Advanced Dissolution, Absorption and Metabolism (ADAM) model is applied to the prediction of formulation-specific FE for BCS/BDDCS Class II drug and CYP3A4 substrate nifedipine using as far as possible only in vitro data.
This model depends only on initial charge density and detonation velocity as inputs, dramatically simplifying the calibration process relative to existing models, which require measurement of up to seven formulation-specific parameters.
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