Current research suggested that mucosal delivery of properly designed formulation of protein-based antigens could provide efficient humoral protection in animal models.
In order to design a sustained-release formulation of protein drugs characterized by excellent long-acting properties without an initial burst, a new double-layer minipellet (DL-MP) in which the lateral side of a matrix-type sustained-release formulation 'minipellet' using collagen as a carrier was coated with collagen was designed, and its performance was evaluated.
Beyond the production phase, serum-derived components have traditionally been used to address challenges associated with the formulation of protein therapeutics.
The results of the present study using SCID mice would be suitable for discussing the in vitro in vivo correlation of protein release from microspheres, and useful for designing long-term release formulations of protein drugs.
Two classic examples include the discovery of the prion protein and formulation of the protein-only hypothesis of prion disease (Bolton et al., 1982), and the discovery of the Alzheimer amyloid peptide (Aβ) (Glenner and Wong, 1984) and formulation of the amyloid cascade hypothesis of Alzheimer's disease (AD, reviewed by Musiek and Holtzman (Musiek and Holtzman, 2015)).
Integration of germ line, transcriptional, and protein expression data brought to the formulation of a protein prediction model strongly predictive of treatment outcome (unpublished own data).
Some degree of mutual accommodation between the protein binding surfaces and RNA causes the formulation of most protein-RNA complexes.
What is more, appropriate formulation of a protein product is highly important, particularly with respect to stabilization, because if this is inadequate the protein may aggregate or denature, which increases its immunogenic potential [ 22].
"There's nothing magic in ours, it's all based on the formulation of the protein and the fiber to satisfy your appetite for a relatively low amount of calories," Mr. Turner said.
