Formulation issues are important as it is necessary to disperse the active substance into a volatile propellant.
The objective of this study was to resolve critical formulation issues in developing nanoparticles (NPs) capable of permeating the blood brain barrier (BBB) and targeting cerebrovascular Aβ proteins.
The specific advantages in using colloidal nanoscale particles and emulsions as delivery systems for micronutrients and nutraceuticals will be discussed and exemplified for the most commonly related formulation issues.
Pharmacokinetic and formulation issues exacerbate the problem of prescribing in children.
As adamantyl ethanone compounds are lipophilic in nature, their solubility in the aqueous phase is rather limited, which could cause formulation issues in in vivo studies.
Earlier Hsp90 inhibitors were not able to achieve an acceptable therapeutic index as their clinical development was hindered by toxicity and formulation issues.
A water-soluble anaesthetic, minaxolone was developed in an attempt to avoid complex formulation issues but was ultimately withdrawn due to an unacceptable level of muscle movement and concerns over carcinogenicity.
If separate investigations were conducted for the analytical and formulation sections, reports should be issued by their respective groups.
Male legislators have an opportunity to examine their own bias as they address only one-half of the family equation, correct a lopsided formulation of issues, and model for our society male as well as female concerns for our children's futures.
The formulation alleviates issues faced by arc flow formulations with regards to handling multiple calls to the same port.
