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The currently available formulation is administered by intravenous (i.v).v
In contrast, the ExBID formulation is administered as a bolus injection prior to the two largest meals of the day and has a systemic half-life of 2.4 h [ 13].
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A single 25 mg dose of each formulation was administered to healthy volunteers.
A single 3.75 mg dose of each formulation was administered to 46 postmenopausal female healthy volunteers.
Capsules containing the active (400 mg DG) or placebo formulation were administered 30 60 min before lunch and dinner throughout the study period.
The liposomal formulation was administered by i.p. route at 3 mg/kg for eight days and reduced the parasite burden to 54% in liver when compared to untreated group; no improvement was observed in the spleen of infected hamsters.
The formulation was administered intralesionally with a syringe.
The antigen-adjuvant formulation was administered in a prime-boost regimen into rabbits, and elicitation of antigen binding and neutralizing antibodies (nAbs) was evaluated.
Each formulation was administered on days 0, 7 and 30.
The study was double-blind with respect to which the DTPw-HBV-IPV/Hib formulation was administered.
Each vaccine formulation was administered intramuscularly (i.m .. Two weeks after each immunisation, animals were bled periodically to obtain serum and peripheral blood mononuclear cells (PBMCs) for immunological analysis.
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