In order to validate the above formulation, Figure 1 shows the analytical and simulated PDF of U1.
The TGI/AUC0-8 ratios normalized relative to plasma exposure were much higher (approximately 16-fold) for nanosuspension delivery compared to the standard formulation (Figure 7).
In order to reduce the computational burden associated with 3D models we reformulate problems (1) and (2) in cylindrical coordinates and assume that they are axis symmetric, reducing then to a 2D formulation (Figure 1).
Our current study in tumor-bearing xenograft mice clearly shows that intravenous delivery of a 20 mg/kg paclitaxel dose using nanosuspension resulted in reduced efficacy compared to the standard Cremophor EL:ethanol formulation (Figure 6).
Centrifugal force was not required for hEB formation using this media formulation (Figure S5F).
Recovery from CSI for the WT channel was again sigmoidal at each HP and empirically fit as an "a2" formulation (Figure 3.C, upper panel).
As expected, rats (500 g; n = 4/group) administered with 0.05 mmole of Gd in LNP exhibited much higher blood Gd concentrations than with the Gd-DTPA formulation (Figure 4).
NHP that were primed and boosted with escalating doses of Fluzone+GLA-SE exhibited higher HI titers not only against the vaccine strain but also to the most recent drifted influenza variant (A/H1N1/Brisbane), a component of the subsequent years vaccine formulation (Figure 4).
The size distributions were monodispersed (0.216 to 0.442) in all the nanoparticle formulations (Figure 1).
Laser diffraction analysis indicated a size distribution profile with the major particle size fraction in the nanometer scale for all formulations (Figure 5).
