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This formulation displayed an acceptable compromise between factors and responses investigated.
In vitro, formulation displayed initial rapid release of the drug followed by rather slow release.
The optimal formulation displayed a double response on joint inflammation and symptomatic pain.
The optimized formulation displayed complete drug delivery and zero-order release rate.
The optimal formulation displayed a particle size of 114 nm with a positive surface charge of +28 mV.
The selected formulation displayed nano-sized spherical vesicles (242.5 ± 6.43 nm) with reasonable entrapment efficiency percent (68.33 ± 2.33%).
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The optimized formulation displays a complete drug delivery and zero-order release rate.
However, each formulation displays enough negative charge to be stable at a physiological pH.
Meanwhile, both formulations displayed low internalization and release at pH greater than 7.
Finally, all investigated formulations displayed excellent cytotoxicity data determined by MTT assay using human retinal pigmented epithelium cells.
With the exception of Tetronic 904, all formulations exhibited Newtonian flow in the nonaqueous state, whereas, all aqueous formulations displayed pseudoplastic flow.
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