Sentence examples for formulation difficulties from inspiring English sources

There are many reasons for this market deficiency including formulation difficulties and identification of suitable existing and new APIs amenable to liquid/soluble formulations.

On the contrary, heuristic methods are suitable for stochastic global search, free from problem formulation difficulties and can escape from premature local optimal.

This review outlines SDLFs as one of the most promising approaches to overcome the formulation difficulties of these hydrophobic/lipophilic drugs.

However, formulation difficulties have halted its clinical development.

However, geldanamycins have several limitations, including poor solubility, formulation difficulties, hepatotoxicity and extensive metabolism by polymorphic enzymes, along with drug efflux by P-glycoprotein (Kelland et al, 1999; Eiseman et al, 2005; Brough et al, 2008; Eccles et al, 2008).

(2, 3) However, geldanamycin derivatives have several limitations, including poor solubility, formulation difficulties, and severe hepatotoxicity in clinical settings,(4– 6) which have prompted development of next generation synthetic HSP90 inhibitors including NVP-AUY922 (aUY922), a second generation isoxazole-based non-geldanamycin HSP90 inhibitor that inhibits the ATPase activity of HSP90.

Traditionally, EM wave absorbing materials, which are composed of magnetic metals or alloys particles, are restricted in application because of high specific gravity and formulation difficulty.

This review is focused on the key challenges of siRNA therapeutics, with special attention on the faced obstacles and on the formulation-related difficulties, providing a list of requirements needed for obtaining an ideal carrier for siRNA.

The DG formulation avoids common difficulties associated with cohesive elements.

By our technique based on the angle formulation, standard numerical difficulties are easily overcome.

During the process of the formulation, numerous mathematical difficulties are encountered to deal with improper integrals suffered by singularities.