By using the emulsion solvent evaporation technique, several process parameters were tested to achieve best preparation conditions, including time of sonication, amount of polymer in the formulation, surfactant content in the formulation, organic to aqueous phase volume ratio and diazepam content.
A comparison method of formulation water content and swelling through gravimetric analysis was also conducted.
On this basis, three main factors affecting the extrusion pressure of bioceramics materials, namely paste formulation (solvent content), nozzle length-to-diameter ratio, and the extrusion velocity, were selected as the control factors, and a series of experiments were performed using the L27 (313) orthogonal array.
For the AS02 formulation, the contents of one vial of lyophilized PfAMA1 containing 62.5 µg of antigen (lot C) was mixed by gentle shaking with AS02 (approximately 0.6 ml) [32].
In all formulations, drug content was not changed obviously during storage.
Instrumental utilization directly relates the formulation and contents of the strategies with research results, and is the least used within the analyzed policies and programs.
Then, a wide experimental program including a total of 40 mixes of mortars with different formulations and contents of accelerators was performed.
A challenging sustained release formulation with high content of a poorly flowing low density drug was selected.
The DCC LyoMate method did not only produce pharmaceutically acceptable cakes but was also able to maintain the desired product temperature irrespective of formulation and protein content.
The constrained mixture experimental design was used to prepare systematic model formulations which were composed of three formulation variables: the content of HPMC (X1), avicel (X2), and sodium alginate (X3).
