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The feeding behavior of each formulation component was investigated by deriving feed factor profiles.
As an edible microalgae, Spirulina is not only a human food supplement, but also valuable as an animal feed formulation component due to its high protein (60 70% dry weight), vitamin, and mineral contents (Harun et al. 2010).
Although some groups have found a negative relationship between the dispersive surface energy of one formulation component and fine particle delivery, such studies often have a number of limitations.
The results demonstrated that the polymeric formulation component, namely, cationic polymethacrylate (Eudragit E100), was the key factor to mask the bitter taste of acetaminophen by inhibiting immediate drug release thereby reducing the interaction intensity of the bitter material with the oral cavity taste buds.
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The film thickness is an essential factor that exhibits the distribution uniformity of formulation components.
Following optimization, the values of formulation components (X1, X2, and X3) were 30%, 50 % and 20, respectively.
DSC thermograms of RB, buccal film formulation components with and without RB are shown in Fig. 6.
Figure 6c shows DSC thermogram of film formulation components with RB, which have slight difference compared to film without RB.
Following optimization, the values of formulation components (X1, X2, and X3) were 32.43%, 29.73% and 21.62%, respectively (16.22% of gemfibrozil).
The formulation components i.e. surfactant, co-surfactant and oil were investigated to construct a pseudoternary phase diagram.
Following optimization, the values of formulation components (X1, X2, and X3) were 34.20%, 40.41% and 25.39%, respectively.
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