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Research must also address issues of formulation, chemical stability/compatibility, pharmacokinetics, and toxicology during clinical development and drug approval.
Formulation, chemical and structural stability, lack of aggregation, solubility, and route of administration are also key factors to consider to minimize immunogenicity of fusion proteins [ 53, 139, 140].
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One of the challenges is to find a balance formulation (chemicals and the mixture fractions) so that all the desired needs and performance are fulfilled.
From these results, it appears that topical creams containing the extracts from photosynthetic bacteria should be effective for treating or at least soothing atopic dermatitis although some of the formulation chemicals (glycerin, Jojoba oil, SC-glucan) in Table 1 could possibly affect skin water content retention and skin protection.
Lowering methane emissions has therefore become a major priority in ruminant livestock production, with many different strategies having been proposed to mitigate emissions, including different dietary formulations, chemical and biological feed additives, chemogenomics and antimethane vaccines [ 4– 6].
The structure of the library is guided by a general modelling concept for the systematic formulation of chemical engineering process models.
This approach is a particular case of the recently proposed formulation in chemical engineering literature by Henderson et al. [N. Henderson, L. Freitas, G.M. Platt, Prediction of critical points: a new methodology using global optimization, AIChE J. 50 (2004) 1300].
Appropriate physicochemical properties are important parameters for compounds to become drugs; they affect the route of administration, pharmacokinetics, pharmacodynamics, formulation and chemical stability of the drug substance.
Gas exchange is parameterized using the Wanninkhof [ 1992] formulation considering chemical enhancement.
Earlier studies demonstrated that increment of CaCl2 in the CO3Ap formulation accelerates chemical reaction to promote particle formation.
The mechanistic model for the PRR pathway, developed according to the stochastic formulation of chemical kinetics, consists of 25 reactions among 23 molecular species.
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