Heberitro (Heber Biotec, Havana, formulation A), a newly developed product and Eprex (CILAG AG, Switzerland, formulation B), as reference treatment were compared.
Type "re" (as reference), press space.
It is usually appropriate to use the immediate-release component of each formulation as the reference and try to adjust for this when switching between MPH formulations.
This paper presents a new finite element formulation, referred to as reference surface element (RSE) model, for numerical prediction of dynamic behaviour of delaminated composite beams and plates using the finite element method.
FURP lamivudine (Fundação para o Remédio Popular, Brazil, as test formulation) and Epivir® (GlaxoSmithKline, Brazil, as reference formulation) were evaluated following a single 150 mg oral dose to 24 healthy volunteers of both genders.
Vonau flash® (Biolab Sanus Farmacêutica, Brazil, as test formulations) and Zofran® (GlaxoSmithKline, Brazil, as reference formulation) were evaluated following a single 8 mg dose to 23 healthy volunteers of both genders.
Clinical study was performed in 64 healthy subjects receiving a subcutaneous dose of an immediate release solution as reference formulation and an intramuscular injection of microspheres as test formulation.
As reference formulations, iv injection of sCT solution (5 μg kg−1), pulmonary sCT solution (25 μg kg−1), and blank nanoparticles dispersion (without sCT) were also included in the study.
Theoretical release profile of drug for controlled release formulation was calculated and considered as reference for the determination of similarity factor (f2) and desimilarity factor (f1). RSM, f2 and f1 were used to select the optimum formulation.
The high concentration emulsion contained 83% silicone fluid 12500 and 15% n-methyl pyrrolidone containing 100 mg/g bucladesine, stabilized with 2% Abil Care 85® resulting in a cream formulation containing 1.5% bucladesine.> As reference solution, bucladesine was dissolved immediately prior to the experiment in a mixture of 100 μl DMSO and 900 μl water at a final concentration of 5%.
