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The torque model of extrusion is obtained and it can provide theoretical bases for process formulation and device design.
Drug delivery strategies for diabetes have included a wide range of scientific and engineering approaches, including molecular design, formulation and device design.
The optimum ANN (9-4-1 ar2hitecture, average r2 0.92 ± 0.02) included active pharmaceutical ingredient, formulation, and device inputs identified by principal component analysis, which reflected the recognized importance and interdependency of these factors for orally inhaled product performance.
During this period innovative formulation and device design has not only increased the diversity of pMDIs that are available, it has also improved their efficiency in targeting drug to the lung.
The characteristics of an ideal DPI, recent innovations in powder formulation and device design are not universally reliable in terms of dose variability, clinical efficacy, user friendliness and economy.
This review provides a critical analysis of factors related to both drug formulation and device features that can have an impact on asthma management.
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Clinical PK data comparing systemic exposure of a lipophilic selective glucocorticoid receptor modulator in healthy volunteers after administration in six different inhalation formulations and devices was shown to correlate better with peripheral lung dose than with total lung dose or total delivered dose.
Successful delivery of dry powder aerosols to the lung requires careful consideration of the powder production process, formulation and inhaler device.
Several factors play a primary role in determining the efficacy of the drug deposition in the large and small airways, and are related to the characteristics of both the drug formulation and the device [ 13].
The rapid improvement in aerosol formulation and delivery devices could greatly change the landscape for therapy against lung cancer (Nanjwade et al, 2001; Gagnadoux et al, 2008).
Due to the drug formulation and the design of devices, different DPIs do not show the same performance and manufacturers are taking a variety of device design approaches.
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formulation and tool
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