With detailed knowledge of the mechanical properties of excipients and formulated powders, we improved the lead formulation by overcoming manufacturability deficiencies using predictive and material sparing (<10 g) approaches.
For all formulated powders, improved dissolution rate was found compared to that of the raw material, making thalidomide promptly available in the nasal environment at a concentration favouring an accumulation in the mucosa.
The possible adverse effects of pressing on bacterial viability were investigated by comparing the viability of cells in tablets with those in formulated powders.
This study provides fundamental insights of how to formulate powder feedstock and aims to support future research activities on the design and development of new alloys for use in powder-based additive manufacturing.
In 2011, Li et al [ 16] characterized the anti-inflammatory activity of YunNan BaiYao (YNBY), aforetime also called Yunnan Pai-yao, which is an amalgamation of various herbs and plants derived from southern China formulated in powder or capsule [ 16].
intracolonic, i.p. intraperitoneal, p.o. per os, SASP salicylazosulfapyridine, TNBS 2,4,6-trinitrobenzenesulfonic acid, UC ulcerative colitis In 2011, Li et al [ 16 ] characterized the anti-inflammatory activity of YunNan BaiYao (YNBY), aforetime also called Yunnan Pai-yao, which is an amalgamation of various herbs and plants derived from southern China formulated in powder or capsule [ 16 ].
Liquisolid powder formulations formulated from a combination of Synperonic® PE/L61 Solutol® HS-15 showed highest dissolution.
The study formulas are formulated into powders and are reconstituted at 13.3%.
Cocoa powder mixtures were formulated with cocoa powders of different fat content (10 12 g/100 g and 16 18 g/100 g) and various sweeteners (carbohydrate sweeteners, sugar alcohols, intense sweeteners, bulking agents) and then subjected to agglomeration.
