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All drugs were formulated in a solution of 5% PEG400 + 5%Tween800 in PBS and delivered in a total volume of 200 μl.
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Usually, the In-oxine solution is formulated in a buffer solution by the manufacturer.
The study was focused on the early formulation step of a very stable drug, Mitonafide (antineoplastic agent), formulated in a parenteral solution and in tablets.
For in vivo studies, gossypol was solubilised in a vehicle solution of 10% ethanol in sterile dH2O (Xu et al, 2005), whereas TMZ was formulated in a vehicle solution of 10% DMSO in sterile D-PBS (Pedretti et al, 2010) as previously described.
In this study, probucol was formulated in an oil solution, two SMEDDS and one nano-emulsifying (SNEDDS) formulation.
ONX 0914 was formulated in an aqueous solution of 10% (w/v) sulfobutylether-β-cyclodextrin and 10 mM sodium citrate (pH 6) and administered to mice as an s.c. or i.v. bolus dose of 6 or 10 mg/kg (in a volume of 100 μl).
However, the clinical intravenous administration of commercially available DTX (Taxotere®) is formulated in a highly concentrated solution containing 40-mg DTX and 1040-mg Tween® 80 (Polysorbate 80) per mL.
The acquired DTX is formulated in a highly concentrated mixed solution containing Polysorbate 80, Phospholipid, and dehydrated alcohol.
For in vivo studies, BAY 87-2243 was formulated in a 1% (v/v) solution of ethanol/solutol/water (10/40/50%).
We measured the in vivo immune response of a vaccine containing 0.25, 1, or 4 μg murine IL-12 and 75 μg ovalbumin (OVA), formulated in a 1.5% chitosan glutamate solution.
Both radiotracers were formulated in an isotonic, sterile and pyrogen-free solution for intravenous (IV) injection.
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