European Molecular Biology Laboratory, Heidelberg 2. Free University of Berlin Medicare The Medicare formulary 44,500 triples; 6800 drugs Primary data 1.
Currently approved molecular targeted therapy Cetuximab has added epidermal growth factor receptor (EGFR), a known EMT-inducer in HNC, to the formulary [5].
ADRs were identified on the basis that they were well recognised as evidenced by their inclusion in either the Summary of Product Characteristics [13] and/or the British National Formulary [14].
†From British National Formulary 65 (March 2013).
Drug prescriptions were analyzed by mapping drug codes to chapter subheadings in the British National Formulary (14).
The unit drug acquisition costs for hormonal and chemotherapies was derived from British National Formulary (British National Formulary, 2006) (Table 3).
All unit costs for resources were taken from nationally published sources, and reported in pounds at 2005 prices (Curtis and Netten, 2005; British National Formulary, 2006).
NHS acquisition costs (not accounting for negotiated procurement discounts in some settings), taken from British National Formulary 51, March 2006 [75]; note that individual doses and thus costs may vary.
23 Symptomatic medication calculations used the cost per dose, according to the British National Formulary, 23 to generate daily costs for the different symptomatic medications.
95% CI = 95% confidence interval; Renal Drug HB = The Renal Drug Handbook (19), Dosing = http://www.dosing.de (21), AMP = Arzneimittel Pocket (22), BNF = British National Formulary (20), DPRF = Drug Prescibing in Renal Failure (18).
Secondly, in case of any effect of ACE inhibitor use on cancer risk, we used those prescribed thiazides and related diuretics (as defined by chapter 2.2.1 of the British National Formulary 11) as an alternative comparator group.
