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We review recent empirical evidence demonstrating that both these forms of variation influence host plant use in this moth.
It appears that I formerly underrated the frequency and value of these latter forms of variation, as leading to permanent modifications of structure independently of natural selection" (Origin of Species, 6th edition, Chapter 15, p. 395, emphasis mine).
Other forms of variation that might affect gene expression should now be considered.
In principle, complex disease might be more susceptible to 'soft' forms of variation such as variation in non-coding sequences or copy number which alter gene dose without abolishing gene function.
While it is well established that more strongly deleterious mutations exhibit evolutionary profiles that differ from more neutral forms of variation in the human genome, it has been challenging to assess how much of a role natural selection has played in weakly deleterious mutations [10].
Classical genetic studies estimate the contribution of all inherited forms of variation.
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Geneticists realized only in 2004 that having extra copies of genes was a widespread form of variation in the human genome.
A similar damped type form of variation was observed at TJO in Iceland.
There is a wide range of allelic variation in human disease genes, and one common form of variation is the Single Nucleotide Polymorphism (SNP).
The latter was now the form of variation to be given primary evolutionary significance, and presumably this was more likely to be transmitted to the offspring, although details are left unclear.
The doctrine of cy-près is a form of variation of trusts; it allows the original purpose of the trust to be altered.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com