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It is well understood that dose response relationships for EDCs may be nonlinear (Birnbaum 2012); thus we reported our results in quartiles as a conservative approach so that potential nonlinear relationships could be examined without making any assumptions about specific forms of the dose response.
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Although mechanistic information may indicate that a particular intermediate step is a key step toward toxicity, that information normally does not specify the form of the dose response for the intermediate variable.
This illustrates that, as pointed out earlier, in such models the estimated low-dose tumor risk is determined by the empirical form assumed for the dose response of the intermediate step(s) in the progression to toxicity.
The slopes of the regressions for the two halves of the data set were used to make inferences on the qualitative form of the dose-response relation: is there a maximum response at intermediate concentrations or not?
For ionizing radiation, the principal uncertainty at present lies in the form of the dose-response relationship.
The present study was designed to establish the form of the dose-response relationship for dietary sodium arsenite as a co-carcinogen with ultraviolet radiation (UVR) in a mouse skin model.
This methodology indicates that extremely low doses of LPS induce ocular permeability changes and that neither the time course nor the dose response of this effect is linear.
The dose response relationship of L. monocytogenes for humans is not known.
Besides, the nonmonotonic form of these dose-response relations raises the problem of their use for the possible establishment of guidelines [ 53].
In the current study a decrease of HDL was observed in association with BMI (in the form of a dose response) and with active smoking, while alcohol consumption (30 or more drinks per month) was associated with an increase of HDL (Table 2).
Hormesis is an attribute of the dose-response or exposure-response relationship.
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