Sentence examples for forms of targeted therapy from inspiring English sources

The aims of this review are, firstly, to discuss current thinking in relation to the role of these genes in the pathogenesis of breast cancer and, secondly, to examine how this evidence may be assimilated such that new forms of targeted therapy can be developed.

However, combining sunitinib with other forms of targeted therapy has been difficult because of excessive toxicity (Feldman et al, 2009).

Drug-eluting beads as an alternative to conventional TACE, and radioembolization, are more recently developed forms of targeted therapy that demonstrate very good early results and offer more options for more advanced disease including PV involvement.

Furthermore, the data suggest that combining multiple forms of targeted therapies may not be analogous to combining different types of cytotoxic chemotherapy, presumably because of unrecognized interactions of intracellular signaling pathways.

Chimeric antigen receptors (CARs) represent an exciting new form of targeted therapy that confers the targeting specificity of mAbs to cytotoxic T cells, the first of which were reported some 25 years ago [69].

Clinical studies have confirmed the prognostic significance of c-Met expression in breast cancer and highlight the potential of c-Met inhibitors as a novel form of targeted therapy.

Since the most widely used form of targeted therapy for breast cancer remains anti-oestrogen endocrine therapy, it is important to know if the ERα status of DTCs corresponds to the ERα status of the primary tumour, particularly in view of the 15 to 20% relapse rate in early stage ERα-positive tumours despite adjuvant endocrine therapy [ 9].

Tyrosine kinase inhibitors (TKIs) are considered a very important class of targeted therapy [8].

Several ongoing trials are evaluating the efficacy of targeted therapy in papillary form.

Forty five years later, his concept of targeted therapy was first demonstrated in the form of an ADC, methotrexate conjugated to a leukemia cell-targeting antibody (Mathe et al., 1958).

understanding immune effects of targeted therapy.