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Normal cells equipped with various forms of repair machinery can replicate and maintain DNA with great accuracy.
If hESCs rely on alternative forms of repair it is possible there would be a difference in the fidelity with which the repair occurs.
ESCs may use several mechanisms to maintain genomic stability including the up-regulation of DNA repair, the utilization of high-fidelity forms of repair, and the efficient elimination of damaged cells by apoptosis [ 2- 5].
Loss of cNHEJ in cells leads to use of alternative, slower forms of repair, resulting in reduced speed by which DSBs are resolved (Kinashi et al., 2011; Vandersickel et al., 2010).
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Catheter ablation for atrial tachycardia in Fontan patients has considerably lower success rates than in other forms of repaired congenital heart disease.
In nucleotide excision repair, the repair machinery recognizes a wide array of distortions in the double helix caused by mismatched bases; in this form of repair, the entire distorted region is excised.
In automotive domain, overwhelming volume of textual data is recorded in the form of repair verbatim collected during the fault diagnosis (FD) process.
All told, an estimated 3.3 million properties require either an inspection or some form of repair work each month.
First, our results show that DNA damage in the form of repair intermediates is insufficient to activate the bulk of the environmental stress response.
This form of repair is extremely efficient and requires a kinase specifically activated by DNA ends, the DNA dependent protein kinase (DNA-PK) [12].
NHEJ is a potentially error-prone form of repair that is initiated with the binding of the KU70/KU80 heterodimer to DNA ends which then recruits the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).
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