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So behavioral economics is one of the main forms of modification of the economic canon.
With both forms of modification, however, the yield rise was so great (9% above non-GM crops for herbicide tolerance and 25% above for insect resistance) that farmers who adopted GM crops made 69% higher profits than those who did not.Many poor countries eschew GM crops, fearing they will not able to export them to areas which ban them, notably the European Union.
Yet another version of this criticism is that we should allow for much less "rationalist" forms of modification of our views, recognizing "conversion" experiences like those involved in "paradigm shifts" may affect any account of coherence.
These two forms of modification have differential impact on Smad4 function.
C-terminal alpha-amidation and N-terminal pyroglutamination are common forms of modification [ 6] and can affect peptide stability [ 7], peptide structure [ 8, 9], and bioactivity [ 10, 11].
Of these elements, the post-translational modification of histones has been of particular interest because of the diversity of the available forms of modification and the number of target amino acids and their physical location within histones.
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Previous studies have reported that post-transcriptional alterations modify the 3'ends of miRNAs via mono/poly-uridylation, polydenylation, adenylation as well as other forms of modifications [ 59– 62].
However, there could be direct or indirect effects on other forms of modifications such as phosphorylation or acetylation that possibly influence its stability.
The antibody has to be able to discriminate between the unmodified and the modified state of the targeted amino acid residue, as well as between different forms of modifications (e.g. acetylations of different lysine residues, mono-, di- and trimethylation of lysine residues, or symmetric and asymmetric methylation of arginine residues).
Cleavage of serine from the C-terminus, which forms truncated αA172, is the most prevalent form of modification that occurs in human eye lens crystallins [10], [15], [16].
Cleavage of amino acid residues at specific sites in the C-terminal end of αA-crystallin constitutes the major form of modification that leads to structural and functional changes in this sHsp/molecular chaperone [10] [16].
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