Two different forms of FIG-ROS fusion were identified (Figure 2A).
Western blot analysis showed that both forms of FIG-ROS fusions activate known downstream effectors of ROS, such as STAT3 and AKT (Figure S2A).
While both forms of FIG-ROS fusions showed increased tyrosine kinase activity in vitro as compared to control, FIG-ROS S) has more than 4 fold higher kinase activity than FIG-ROS L) (Figure S2D).
The final reaction network takes the form of Fig. 2.
The reaction network is assumed in its most general form of Fig. 1 (ri's denote reaction rates of different species).
Thus the model in the form of Fig. 2b is also scalable, and the monotonic dependence of availability on security indices remains true.
Presenting the results in the form of Fig. 3, combines relevant information that is required to help make decisions on whether the daily baseline values need to be updated.
Similar to the proof that the MCDCM problem is NP-hard in "Minimum cuts in correlated networks" section, the MC-SRLG problem in the form of Fig. 6 can be reduced to the NP-hard SP-SRLG problem.
It is noteworthy that these sequences are of human origin and appear to have adopted G2 like forms of R1 (Fig 1B, 1C, Fig 2 R1 tree).
This analysis also revealed the presence of several distinct forms of SPAK (Fig S3C), but only one species of OSR1 (Fig S3D).
