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Apoptosis and necrosis are two morphologically distinct forms of cell death that are important for maintaining of cellular homeostasis.
Reduction of necroinflammatory activity is a major goal of antiviral therapy of patients with chronic hepatitis B. Serum ALT does not detect all forms of cell death.
However, excessive autophagy can influence several forms of cell death, including caspase-independent cell death and apoptosis [18] [24].
Recent studies have shown an apoptosis-necrosis continuum for these two major forms of cell death [47].
Mitochondria play a key role in regulating the apoptotic mechanisms and also in some forms of cell death by necrosis [12], [13].
The possibility of altered forms of cell death active in neuronal lineages versus other cell types is another important consideration [32].
Several forms of cell death have been identified.
Apoptosis and necrosis are two major forms of cell death, which show distinct morphological appearance.
Lysosomes and lysosomal proteases also participate in apoptotic and necrotic forms of cell death [ 118- 120].
This assay has the advantage of measuring all forms of cell death, not just apoptosis.
Three major forms of cell death have been described based on morphological criteria.
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