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These forms of cell injury can include apoptosis, loss of cell-forming gaps in the tubular architecture and denuded basement membranes, and cells sloughing into tubular lumens [9].
Apoptosis can occur concomitantly with other forms of cell death.
Different forms of cell death in the treated samples were quantified and represented in Figure 2d.
Three classical forms of cell death apoptosis, autophagy, and necrosis display distinct morphological features by activating specific signaling pathways2.
Additional model systems demonstrating that NFS1 suppression sensitizes cells to ferroptosis versus other forms of cell death.
This highlights the essential requirement of an approach with a real-time analysis capability for discriminating the two forms of cell death.
Overall, the approach described is highly adaptable for cancer drug screening purpose utilizing HTS imager and can efficiently discriminate between the two forms of cell death.
Both forms of cell death are involved in several physiological and pathological conditions and also in the elimination of cancer cells following successful chemotherapy.
Apoptosis and necrosis are two morphologically distinct forms of cell death that are important for maintaining of cellular homeostasis.
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JNK is involved in several forms of cell-specific and stress-induced apoptosis, which are dependent on cell type and stimulus.
Similarly, a transient increase in unintegrated episomal forms of cell-associated HIV-1 DNA was observed following treatment intensification with raltegravir [62].
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