During the following visit, investigators interviewed the children and their parents, transcribed events into case report forms, and assessed whether they were vaccine-related.
Two assessors reviewed titles, abstracts, and full articles using standardised data abstraction forms and assessed study quality.
Data extraction: Paired reviewers extracted detailed information from included articles on standardized forms and assessed the risk of bias in each article.
Two authors independently screened retrieved references for inclusion (FK, HB), and two authors (FK, AB) independently extracted data using standardised data extraction forms and assessed each study's risk of bias.
Each indicator was individually validated using the obtained case registration forms and assessed with respect to the following quality criteria: applicability, feasibility, adherence to the indicator and improvement potential [ 18, 20, 21].
Two authors (PK and BH or BG) independently extracted information from each included trial by using standard data extraction forms, and assessed the risk of bias as defined in The Cochrane Handbook of Systematic Reviews of Interventions.
Two authors (BH and CH or TA) independently extracted information from each included trial by using standard data extraction forms and assessed the risk of bias as advised in the Cochrane Handbook of Systematic Reviews of Interventions.
Incidence of ocular adverse events reported on the case report forms and assessed by the investigator was low with all doses, but a modest, dose related incidence of chromatopsia, cyanopsia, photophobia, and visual disturbance was reported with 80 mg three times daily consistent with the indicated dosing for erectile dysfunction.
"The benchmark for a lot of the squad was the Six Nations and then looking at some club form and assessing whether there was the same physical intensity to draw comparison and then finally make the selection of those players.
They discussed those papers deemed potentially eligible, independently extracted data (baseline characteristics, definition of outcomes, numbers of events) using a standardised data abstraction form, and assessed studies' methodological quality using the risk of bias assessment tool from the Cochrane Handbook for randomised trials.
