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We recently described a highly enriched TIC population from the bone marrow of patients with often-fatal relapse NB that forms aggressive metastatic tumours when as few as 10 cells are orthotopically transplanted into immune compromised mice (Hansford et al, 2007).
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We showed previously that BRCA1-IRIS-overexpressing HME cells form aggressive TNBC tumors lacking BRCA1 expression [ 38].
Although pRB inactivation is an initiating event in the development of many different types of tumors, cells must accrue additional changes to form aggressive tumors.
In the past, intracranial HPCs have been considered a variant form of aggressive meningioma (angioblastic meningioma).
25 Meta-analytic review of aggression research has, however, supported two overall forms of aggressive behaviour.
Bullying involves verbal or psychological forms of aggressive (hostile) behavior that persists for six months or longer.
24 25 Researchers have identified multiple forms of aggressive behaviour and the outcomes predicted by each differ.
While most learn prosocial behaviour within nurturing relationships, others may learn subtle forms of aggressive behaviour.
26 27 The second form of aggressive behaviour may be termed indirect, 28 29 social 30 31 or relational aggression.
The players had formed an aggressive union, salaries were skyrocketing, fans were disillusioned.
NWA split up not long after I had left King's but this form of aggressive rap music lived on.
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